The Donnell House in Athens, Limestone County, functions as a historic house museum and event space. The two-story structure was constructed by Presbyterian minister Robert Donnell (1784-1855), who came to north Alabama in the 1820s as a missionary from North Carolina by way of Tennessee. The house was used by the Athens public school system for many years as a residence for principals, and it remains on the campus of Athens Middle School.


Also in 1869, Judge Joshua P. Coman established the Athens Male College in the house. Ten years later, the boys' school was purchased by the city and merged with the Athens public school system. It would remain part of the city's public school campus until 1889, when it was deeded to the North Alabama Experiment Station and Agricultural School. The house was documented by the Historic American Building Survey in 1935 and was obtained by the city again in 1936 and used as an educational facility. The house served as the residence of the public school's principals until 1970, when the late Julian Newman Sr. retired after serving as principal for 25 years. The house was added to the National Register of Historic Places (NRHP) in 1973, but the Athens school board intended to demolish the home despite its history and condition. In the late 1970s, however, efforts to save and restore the home were implemented and led by local historians Christine W. Edwards and Faye A. Axford and supported by the Limestone Historical Society. In 1994, the house was incorporated under the Donnell House Board, which now holds a 99-year lease on the property from the Athens Board of Education.
Construction on the home began in 1840 and this phase ended sometime between 1849 and 1851. It initially was T-shaped, consisting of a two-story portico across the front section with a central wing. Rooms were eventually added on both sides of the house making it rectangular. The present location of the kitchen, office, and restroom was originally a porch where food was brought into the dining room and also was the location where Donnell held prayer service twice a day. The roof is gabled and there are two exterior chimneys at either side of the home. A third chimney is located in the rear of the central wing. The four square columns at the front of the house form a portico and support a pediment. The main entrance is framed with a transom window over the door, a sidelight on either side, and a rectangular architrave, or main beam. Above the main entrance is a doorway with access to a small balcony fronted by a wooden balustrade.

The Donnell House is located at 601 South Clinton Street. It hosts events throughout the year, such as a Christmas tree presentation during the holiday season. Because it is located on the campus of the Athens Middle School, students have conducted school projects, including interpretive videos that are centered around this history of the house. The house is also available for hosting events such as weddings, receptions, dinners, birthday parties, reunions, and luncheons. Guided tours are available for visitors, but parties must make an appointment to tour the home. There is a gift store on site that sells reproduction boot scrapers made by local metal worker and artist Travis Flemming. The Lure and Love of Limestone County, written by Christine Edwards, Faye Axford, and architectural historian Robert Gamble, is also for sale in the gift shop.