The Alabama School of Mathematics and Science (ASMS) is the state's only fully public residential high school for sophomores, juniors, and seniors seeking advanced studies in mathematics, science, and the humanities. Located in Mobile's Old Dauphin Way Historic District, ASMS was established in 1989 by the Alabama State Legislature to identify, challenge, and train Alabama's future leaders. Tuition, room, and board are free.

In 1989, the legislature approved a bill creating ASMS and gave the school's founders $330,000 in start-up funds to hire faculty and staff and to purchase books and office equipment. Shortly after that, the ASMS Foundation, a non-profit organization located in Mobile that receives donations from businesses, industries, individuals, and other foundations, was created to raise additional funds to purchase a school campus and to furnish labs and dorm rooms. The 12.3-acre ASMS campus sits on the former property of Mobile Dauphin Way Baptist Church, although it has been heavily modified and refurbished. The first students arrived in 1991, while much of the campus was under construction, and the school later added a boys' dormitory and the Ann Smith Bedsole Library.

ASMS has the capacity to enroll 270 students each year. Throughout the school's history, ASMS has enrolled a student from every Alabama county. One hundred percent of ASMS graduates matriculate to college, and nearly 60 percent of these students pursue fields relating to math or science. Since 1993, ASMS has graduated more than 2,200 students, more than 800 of whom have earned post-graduate degrees.
Many courses are taught at the advanced placement or honors level, and students are taught by an experienced 27-member faculty, of whom nearly 55 percent hold doctoral or terminal degrees. Varsity and intramural sports, residential-life activities, and college counseling complement the strong academic program, which is comprehensive in the sciences as well as the humanities. ASMS is a diverse campus: historically, 34 percent of the student body has self-identified as members of ethnic minority groups.

During Special Projects Week, students leave normal classes and study a subject in depth. Some stay on campus and work in labs while others travel off campus. Recently, students have travelled to Italy, China, Puerto Rico, Mexico, Spain, Florida, New York, and Washington, D.C. During this time, students explore topics through research and interactive experiences.
Since its inception, more than 140 students have been recognized as National Merit Finalists, and ASMS graduates have earned more than $170 million in scholarships since 2000.