Anniston Army Depot was originally conceived as an ammunition storage site in the isolated northeast Alabama foothills of the Appalachian Mountains before the United States' entry into World War II. It has since grown to encompass a variety of maintenance and storage missions that keeps the U.S. Army prepared for engagement worldwide. With more than 3,500 people working on the depot in 2021, it is one of Alabama's single largest employers.

Maintenance Missions
After World War II, the depot continued primarily as a storage facility and regional vehicle maintenance depot until 1952, when the Army assigned the depot the mission of overhauling and rebuilding its fleet of combat vehicles and tanks, as well as artillery and anti-aircraft artillery. In addition, the depot was tasked to modify equipment and weapon systems to further extend their usefulness to the Army. In August 1962, the depot was renamed Anniston Army Depot (ANAD) and placed within the Army Materiel Command to better reflect ANAD's growing maintenance role. In 1980, the Army's land-combat missile inventory was added as part of the depot's maintenance function. Employees at the depot repair, recondition, and upgrade missiles such as the Tube-launched Optically Wire-guided (TOW) family of anti-tank missiles and recycles those deemed obsolete for their parts, saving the Army the expense of purchasing some new parts.

For the first time in ANAD's history, new armored vehicles are being constructed on the depot. Currently, Contractor General Dynamics Land Systems builds Stryker vehicles at the depot. These eight-wheeled, highly-mobile armored vehicles have proven invaluable to light infantry units, especially in urban areas, providing fire support and armored protection to units that traditionally rode to battle in unarmored trucks.
Storage
With the end of World War II, the Army faced the challenge of bringing home and storing the millions of weapons that had equipped the 16 million American service members who went to war. ANAD stored many of these weapons until they were disposed of as surplus or demilitarized through destruction. Today, ANAD maintains the entire inventory of the Army's small arms, from pistols to heavy machine guns. Serviceable weapons are refurbished and put back into use, whereas badly damaged and worn out weapons are reduced to indistinguishable pieces before being sold as scrap metal.
Beginning in 1963, ANAD became one of the Army's storage sites for its growing stockpile of Cold War-era chemical-warfare munitions, which included lethal nerve, blood, and blister agents contained in rockets, artillery shells, and aerosol canisters. In the early 1980s, when it was discovered that some of the chemical munitions had begun to leak their deadly payload, a new, state-of-the-art facility was constructed on the depot for the decontamination and destruction of these unstable munitions. The facility was completed in 2001, and in 2003 personnel began to destroy all outdated stockpiles of chemical munitions held at the depot. This disposal process is now mainly complete and was accomplished without incident.
